Publications

Resource Optimization Network

2022

Virtual home-based palliative care during COVID-19: A qualitative exploration of the patient, caregiver, and healthcare provider experience.

Vincent D, Peixoto C, Quinn KL, Kyeremanteng K, Lalumiere G, Kurahashi AM, Gilbert N, Isenberg SR. Virtual home-based palliative care during COVID-19: A qualitative exploration of the patient, caregiver, and healthcare provider experience. Palliat Med. [Epub ahead of print] doi: 10.1177/02692163221116251.

Increased Mortality and Costs Associated with Adverse Events in Intensive Care Unit Patients.

Cantor N, Durr KM, McNeill K, Thompson LH, Fernando SM, Tanuseputro P, Kyeremanteng K. Increased Mortality and Costs Associated with Adverse Events in Intensive Care Unit Patients. J Intensive Care Med. 2022 Aug; 37(8):1075-1081. doi: 10.1177/08850666221084908.

“Everything has been tried and his heart can’t recover…”: A Descriptive Review of “Do Everything!” in the Archive of Ontario Consent and Capacity Board.

Yim H, Hashmi SS, Dewar B, Dyason C, Kyeremanteng K, Lamb S, Shamy M. “Everything has been tried and his heart can’t recover…”: A Descriptive Review of “Do Everything!” in the Archive of Ontario Consent and Capacity Board. BMC Med Ethics
2022 Jun; 23(1):66. doi: 10.1186/s12910-022-00796-7.

Accuracy of presenting symptoms, physical examination, and imaging for diagnosis of ruptured abdominal aortic aneurysm: Systematic review and meta-analysis.

Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. VTE Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis. Chest 2022 Feb; 161(2):418-428. doi: 10.1016/j.chest.2021.08.050.

Development and evaluation of an evidence-based, theory-grounded online Clinical Frailty Scale tutorial.

Haddad T, Mulpuru S, Salter I, Hladkowicz E, Des Autels K, Gagne S, Bryson GL, McCartney CJL, Huang A, Huang S, Forster A, van Walraven C, Kyeremanteng K, Fernando SM, Nagpal S, Moloo H, Boet S, Le Blanc V, Lalu MM, McIsaac DI. Development and evaluation of an evidence-based, theory-grounded online Clinical Frailty Scale tutorial. Age Ageing. 2022 Feb;51(2):afab258. doi: 10.1093/ageing/afab258.

Efficacy and Safety of Low Molecular Weight Heparin Versus Unfractionated Heparin for Prevention of Venous Thromboembolism in Trauma Patients: A Systematic Review and Meta-analysis

Tran A, Fernando SM, Carrier M, Siegal DM, Inaba K, Vogt K, Engels PT, English SW, Kanji S, Kyeremanteng K, Lampron J, Kim D, Rochwerg B. Ann Surg. 2022 Jan; 275(1):19-28. doi: 10.1097/SLA.0000000000005157.

Accuracy of presenting symptoms, physical examination, and imaging for diagnosis of ruptured abdominal aortic aneurysm: Systematic review and meta-analysis

Fernando SM, Tran A, Cheng W, Rochwerg B, Strauss SA, Mutter E, McIsaac DI, Kyeremanteng K, Kubelik D, Jetty P, Nagpal SK, Thiruganasambandamoorthy V, Roberts DJ, Perry JJ. Acad Emerg Med. 2022 April; 29(4): 486-496. doi: 10.1111/acem.14475.

Prognostic Factors Associated With Development of Venous Thromboembolism in Critically Ill Patients-A Systematic Review and Meta-Analysis.

Tran A, Fernando SM, Rochwerg B, Cook DJ, Crowther MA, Fowler RA, Alhazzani W, Siegal DM, Castellucci LA, Zarychanski R, English SW, Kyeremanteng K, Carrier M. Crit Care Med. 2022 Apr; 50(4):e370-e381. doi: 10.1097/CCM.0000000000005382.

Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis.

Tran A, Fernando SM, Brochard LJ, Fan E, Inaba K, Ferguson ND, Calfee CS, Burns KEA, Brodie D, McCredie VA, Kim DY, Kyeremanteng K, Lampron J, Slutsky AS, Combes A, Rochwerg B. Euro Respir J. 2022 Apr; 59(4):2100857. doi: 10.1183/13993003.00857-2021.

2021

Short- and long-term health care resource utilization and costs following intracerebral hemorrhage

Neurology; Fernando SM, Qureshi D, Talarico R, Dowlatshahi D, Sood MM, Smith EE, Hill MD, McCredie VA, Scalees DC, English SW, Rochwerg B, Tanuseputro P, Kyeremanteng K.

Suicide and self-harm in adult survivors of critical illness: Population based cohort study

BMJ; Fernando SM, Qureshi D, Sood MM, Pugliese M, Talarico R, Myran DT, Herridge MS, Needham DM, Rochwerg B, Cook DJ, Wunsch H, Fowler RA, Scales DC, Bienvenu OJ, Rowan KM, Kisilewicz M, Thompson LH, Tanuseputro P, Kyeremanteng K.

Delirium and associated length of stay and costs in critically ill patients

Crit Care Res Pract; Dziegielewski C, Skead C, Canturk T, Webber C, Fernando SM, Thompson LH, Foster M, Ristovic V, Lawlor PG, Chaudhuri D, Dave C, Herritt B, Bush SH, Kanji S, Tanuseputro P, Thavorn K, Rosenberg E, Kyeremanteng K.

Intracerebral hemorrhage incidence, mortality, and association with oral anticoagulation use: A population study

Stroke; Fernando SM, Qureshi D, Talarico R, Tanuseputro P, Dowlatshahi D, Sood MM, Smith EE, Hill MD, McCredie VA, Scales DC, English SW, Rochwerg B, Kyeremanteng K.

Transradial versus transfemoral access for percutaneous coronary intervention in ST-segment-elevation myocardial infarction: A systematic review and meta-analysis

Circ Cardiovasc Interv; Di Santo P, Simard T, Wells GA, Jung RG, Ramirez FD, Boland P, Marbach JA, Parlow S, Kyeremanteng K, Coyle D, Fergusson D, Russo JJ, Chong A-Y, Froeschl M, So DY, Dick A, Glover C, Labinaz M, Hibbert B, May ML.

Media portrayals of outcomes after extracorporeal membrane oxygenation

JAMA Intern Med; Fernando SM, Mathew R, Slutsky AS, Rochwerg B, Kyeremanteng K, Combes A, Brodie D.

Content analysis and characterization of medical tweets during the early COVID-19 pandemic

Cureus; Prager R, Pratte MT, Unni RR, Bala S, Ng Fat Hing N, Wu K, McGrath TA, Thomas A, Thoma B, Kyeremanteng K.

Can early warning systems enhance detection of high risk patients by rapid response teams?

J Intensive Care Med; Reardon PM, Seely AJE, Fernando SM, Didcote S, Strachan I, Baudino J-L, Kyeremanteng K.

Chemotherapy for non-small cell lung cancer in the intensive care unit

Cancer Treat Res Commun; Nasser A, Hartwick M, Kyeremanteng K, Wheatley-Price P.

2020

Predictors of mortality and cost among surgical patients requiring rapid response team activation

Can J Surg; Tran A, Fernando SM, McIsaac DI, Rochwerg B, Mok G, Seely AJE, Kubelik D, Inaba K, Kim DY, Reardon PM, Shen J, Tanuseputro P, Thavorn K, Kyeremanteng K.

Lung-protective ventilation and associated outcomes and costs among patients receiving invasive mechancial ventilation in the emergency department

Chest; Fernando SM, Fan E, Rochwerg B, Burns KEA, Brochard LJ, Cook DJ, Walkley AJ, Ferguson ND, Hough CL, Brodie D, Seely AJE, Thiruganasambandamoorthy V, Perry JJ, Tran A, Tanuseputro P, Kyeremanteng K.

Case discussions in advanced care planning

Am J Hosp Palliat Care; Krechowicz R, Gupta M, Gratton V, Hickey C, Thompson LH, Kyeremanteng K.

Outcomes and resource utilization among patients admitted to the Intensive Care Unit following acute exacerbation of chronic obstructive pulmonary disease

J Intesnive Care Med; Warwick M, Fernando SM, Aaron SD, Rochwerg B, Tran A, Thavorn K, Mulpuru S, McIsaac DI, Thompson LH, Tanuseputro P, Kyeremanteng K.

Long-term mortality and costs following use of Impella® for mechanical circulatory support: a population-based cohort study

Can J Anaesth; Fernando SM, Qureshi D, Tanuseputro P, Talarico R, Hibbert B, Mathew R, Rochwerg B, Belley-Côté EP, Fan E, Combes A, Brodie D, Schmidt M, Simard T, Di Santo P, Kyeremanteng K.

Frailty is associated with decreased time spent at home after critical illness: A population-based study

J Intensive Care Med; Henden A, Tanuseputro P, McIsaac DI, Hsu AT, Smith GA, Begum J, Thompson LH, Stelfox HT, Reardon P, Herritt B, Chaudhuri D, Rosenberg E, Kyeremanteng K.

Pre-arrest and intra-arrest prognostic factors associated with survival following traumatic out-of-hospital cardiac arrest- A systematic review and meta-analysis

Resuscitation; Tran A, Fernando SM, Rochwerg B, Vaillancourt C, Inaba K, Kyeremanteng K, Nolan JP, McCredie VA, Petrosoniak A, Hicks C, Haut ER, Perry JJ.

Frailty and associated prognosis among older emergency department patients with suspected infection: A prospective, observational cohort study

CJEM; Fernando SM, Guo KH, Lukasik M, Rochwerg B, Cook DJ, Kyeremanteng K, Perry JJ.

Diagnosis of ventilator-associated pneumonia in critically ill adult patients- a systematic review and meta-analysis

Intensive Care Med; Fernando SM, Tran A, Cheng W, Klompas M, Kyeremanteng K, Mehta S, English SW, Muscedere J, Cook DJ, Torres A, Ranzani OT, Fox-Robichaud AE, Alhazzani W, Munshi L, Guyatt GH, Rochwerg B.

Long-term survival and costs following extracorporeal membrane oxygenation in critically ill children- a population-based cohort study

Crit Care; Fernando SM, Qureshi D, Tanuseputro P, Dhanani S, Guerguerian A-M, Shemie SD, Talarico R, Fan E, Munshi L, Rochwerg B, Scales DC, Brodie D, Thavorn K, Kyeremanteng K.

A systematic review of interventions aiming to improve communication of prognosis to adult patients

Patient Educ Couns; Selim S, Kunkel E, Wegier P, Tanuseputro P, Downar J, Isenberg SR, Li A, Kyeremanteng K, Manuel D, Kobewka DM.

Costs and Outcomes of Patients Admitted to the Intensive Care Unit With Cancer

J Intensive Care Med; Zheng B, Reardon PM, Fernando SM, Webber C, Thavorn K, Thompson LH, Tanuseputro P, Munshi L, Kyeremanteng K.

New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults- a multicenter retrospective cohort study

Crit Care; Fernando SM, Mathew R, Hibbert B, Rochwerg B, Munshi L, Walkey AJ, Møller MH, Simard T, Di Santo P, Ramirez FD, Tanuseputro P, Kyeremanteng K.

Frailty and associated outcomes and resource utilization following in-hospital cardiac arrest

Resuscitation; Fernando SM, McIsaac DI, Rochwerg B, Cook DJ, Bagshaw SM, Muscedere J, Munshi L, Nolan JP, Perry JJ, Downar J, Dave C, Reardon PM, Tanuseputro P, Kyeremanteng K.

2019

An Analysis of Pay-for-Performance Schemes and Their Potential Impacts on Health Systems and Outcomes for Patients

Crit Care Res Pract; Kyeremanteng K, Robidoux R, D’Egidio G, Fernando SM, Neilipovitz D.

Frailty and Associated Outcomes and Resource Utilization Among Older ICU Patients With Suspected Infection

Crit Care Med; Fernando SM, McIsaac D, Perry JJ, Rochwerg B, Bagshaw SM, Thavorn K, Seely AJE, Forster AJ, Fiest KM, Chintan D, Tran A, Reardon P, Tanuseputro P, Kyeremanteng K.

Why is it so hard to stop doing things that are unwanted, non-beneficial, or unsustainable?

Lancet Respir Med; Kyeremanteng K, Downar J.

Outcomes and cost of patients with terminal cancer admitted to acute care in the final 2 weeks of life: A retrospective chart review

Am J Hosp Palliat Care; Kyeremanteng K, Ismail A, Wan C.

Comparison of outcomes and costs between adult diabetic ketoacidosis patients admitted to the ICU and step-down unit

J Crit Care; Fernando SM, Bagshaw SM, Rochwerg B, McIsaac, DI, Thavorn K, Forster AJ, Tran A, Reardon PM, Rosenberg E, Tanuseputro P, Kyeremanteng K.

Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis

BMJ; Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Kyeremanteng K, English SW, Sekhon MS, Griesdale DEG, Dowlatshahi D, McCredie VA, Wijdicks EFM, Almenawer SA, Inaba K, Rajajee V, Perry JJ.

Mortality and costs following extracorporeal membrane oxygenation in critically ill adults: a population-based cohort study

J. Intensive Care Med; Fernando SM, Qureshi D, Tanuseputro P, Fan E, Munshi L, Rochwerg B, Talarico R, Scales DC, Brodie D, Dhanani S, Guerguerian A, Shemie SD, Thavorn K, Kyeremanteng K.

Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy

J. Intensive Care Med; Fernando SM, McIsaac DI, Rochwerg B, Bagshaw SM, Muscedere J, Munshi L, Ferguson ND, Seely AJE, Cook DJ, Dave C, Tanuseputro P, Kyeremanteng K.

Hospital resource use and costs among abdominal aortic aneurysm repair patients admitted to the intensive care unit

J Vasc Surg; Fernando SM, McIsaac DI, Dalibor K, Rochwerg B, Thavorn K, Montroy K, Halevy M, Ulrich E, Hooper J, Tran A, Nagpal S, Tanuseputro P, Kyeremanteng K.

Preadmission antiplatelet use and associated outcomes and costs among ICU patients with intracranial hemorrhage

J Intensive Care Med; Fernando SM, Rochwerg B, English SW, Thavorn K, McCredie VA, Dowlatshahi D, Perry JJ, Wijdicks EFM, Reardon PM, Tanuseputro P, Kyeremanteng K.

Prognostic accuracy of the Hamilton Early Warning Score (HEWS) and National Early Warning Score 2 (NEWS2) among hospitalized patients assessed by a rapid response team

Crit Care; Fernando SM, Fox-Robichaud AE, Rochwerg B, Cardinal P, Seely AJE, Perry JJ, McIsaac DI, Tran A, Skitch S, Tam B, Hickey M, Reardon PM, Tanuseputro P, Kyeremanteng K.

Ethical failings of CPSO policy and the health care consent act: case review

BMC Med Ethics; Landry JT, Patel R, Neilipovitz D, Kyeremanteng K, D’Egidio G.

Do-Not-Resuscitate and Do-Not-Hospitalize Orders in Nursing Homes: Who Gets Them and Do They Make a Difference?

J Am Med Dir Assoc; Tanuseputro P, Hsu A, Chalifoux M, Talarico R, Kobewka D, Scott M, Kyeremanteng K, Perri G.

Survey on Barriers to Critical Care and Palliative Care Integration

Am J Hosp Palliat Care; Kyeremanteng K, Beckerleg W, Wan C, Vanderspank-Wright B, D’Egidio G, Sutherland S, Hartwick M, Gratton V, Sarti AJ.

Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration

Crit Care; Gershkovich B, Fernando SM, Herritt B, Castellucci LA, Rochwerg B, Munshi L, Mehta S, Seely AJE, McIsaac DI, Tran A, Reardon PM, Tanuseputro P, Kyeremanteng K.

Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol)

BMJ; Alaifan T, Alenazy A, Xiang Wang D, Fernando SM, Spence J, Belley-Cote E, Fox-Robichaud A, Ainswoth C, Karachi T, Kyeremanteng K, Zarychanski R, Whitlock R, Rochwerg B.

Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital arrest: systematic review and meta-analysis

BMJ; Fernando SM, Tran A, Cheng Wm ,Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ.

Economic evaluations of palliative care models: A systematic review

Palliat Med; Mathew C, Hsu AT, Prentice M, Lawlor P, Kyeremanteng K, Tanuseputro P, Welch V.

Impact of Anticoagulation on Mortality and Resource Utilization Among Critically Ill Patients with Major Bleeding

Crit Care Med; Fernando SM, Mok G, Castellucci LA, Dowlatshahi D, Rochwerg B, McIsaac DI, Carrier M, Wells PS, Bagshaw SM, Fergusson DA, Tanuseputro P, Kyeremanteng K.

2018

Dynamic assessment of fluid responsiveness in surgical ICU patients through stroke volume variation is associated with decreased length of stay and costs: A systematic review and meta-analysis

J Intensive Care Med; Dave C, Shen J, Chaudhuri D, Herritt B, Fernando SM, Reardon PM, Tanuseputro P, Thavorn K, Neilipovitz D, Rosenberg E, Kubelik D, Kyeremanteng K.

Characteristics, outcomes, and cost patterns of high-cost patients in the intensive care unit

Crit Care Res Pract; Reardon PM, Fernando SM, Van Katwyk S, Thavorn K, Kobewka D, Tanuseputro P, Rosenberg E, Wan C, Vanderspank-Wright B, Kubelik D, Devlin RA, Klinger C, Kyeremanteng K

Cost analysis of omega-3 supplementation in critically ill patients with sepsis.

Clin Nutr ESPEN; Kyeremanteng K, Shen J, Thavorn K, Fernando SM, Herritt B, Chaudhuri D, Tanuseputro P.

Emergency department disposition decisions and associated mortality and costs in ICU patients with suspected infection

Crit Care; Fernando SM, Rochwerg B, Reardon PM, Thavorn, K, Seely AJE, Perry JJ, Barnaby DP, Tanuseputro P, Kyeremanteng K.

Factors associated with delayed rapid response team activation.

J Crit Care; Reardon PM, Fernando SM, Murphy K, Rosenberg E, Kyeremanteng K.

Impact of nighttime Rapid Response Team activation on outcomes of hospitalized patients with acute deterioration.

Crit Care; Fernando SM, Reardon PM, Bagshaw SM, Scales DC, Murphy K, Shen J, Tanuseputro P, Heyland DK, Kyeremanteng K.

Necrotizing soft tissue infection: Diagnostic accuracy of physical examination, imaging, and LRINEC score: A systematic review and meta-analysis.

Ann Surg; Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ.

Outcomes and costs of patients admitted to the intensive care unit due to accidental or intentional poisoning

J Intensive Care Med; Fernando SM, Reardon PM, Ball IM, van Katwyk S, Thavorn K, Tanuseputro P, Rosenberg E, Kyeremanteng K.

Outcomes and costs of patients admitted to the ICU due to spontaneous intracranial hemorrhage

Crit Care Med; Fernando SM, Reardon PM, Dowlatshahi D, English SW, Thavorn K, Tanuseputro P, Perry JJ, Rosenberg E, Wijdicks EF, Heyland DK, Kyeremanteng K.

Prevalence, risk factors, and clinical consequences of recurrent activation of a rapid response team: A multicenter observational study.

J Intensive Care Med; Fernando SM, Reardon PM, Scales DC, Murphy K, Tanuseputro P, Heyland DK, Kyeremanteng K.

The impact of reducing intensive care unit length of stay on hospital costs: evidence from a tertiary care hospital in Canada

Can J Anaesth; Evans J, Kobewka D, Thavorn K, D’Egidio G, Rosenberg E, Kyeremanteng K.

Early vs. late tracheostomy in intensive care settings: Impact on ICU and hospital costs

J Crit Care; Herritt B, Chaudhuri D, Thavorn K, Kubelik D, Kyeremanteng K.

Cost analysis of noninvasive helmet ventilation compared with use of noninvasive face mask in ARDS

Can Respir J; Kyeremanteng K, Gagnon LP, Robidoux R, Thavorn K, Chaudhuri D, Kobewka D, Kress JP.

2017

Sepsis-3 septic shock criteria and associated mortality among infected hospitalized patients assessed by a response team.

Chest; Fernando SM, Reardon PM, Rochwerg B, Shapiro NI, Yealy DM, Seely AJE, Perry JJ, Barnaby DP, Murphy K, Tanuseputro P, Kyeremanteng K.

Neuroscience intermediate-level care units staffed by intensivists: Clinical outcomes and cost analysis

J Intensive Care Med; Kyeremanteng K, Hendin A, Bhardwaj K, Thavorn K, Neilipovitz D, Kubelik D, D’Egidio G, Stotts G, Rosenberg E.

Early renal replacement therapy versus standard care in the ICU

J Intensive Care Med; Chaudhuri D, Herritt B, Heyland D, Gagnon LP, Thavorn K, Kobewka D, Kyeremanteng K.

Cost analysis of the very elderly admitted to intensive care units

Crit Care; Chin-Yee N, D’Egidio G, Thavorn K, Heyland D, Kyeremanteng K.

Critical care at the end of life: a population-level cohort study of cost and outcomes

Crit Care; Chaudhuri D, Tanuseputro P, Herritt B, D’Egidio G, Chalifoux M, Kyeremanteng K.

2016

Effectiveness of an extended period of flashing lights and strategic signage to increase the salience of alcohol-gel dispensers for improving hand hygiene compliance

Am J Infect Control; Rashidi B, Li A, Patel R, Harmsen IE, Sabri E, Kyeremanteng K, D’Egidio G.

Approach to economic analysis in critical care

J Crit Care; Kyeremanteng K, Wan C, D’Egidio G, Neilipovitz D.

The impact of palliative care consultation in the ICU on length of stay: A systematic review and cost evaluation

J Intensive Care Med; Kyeremanteng K, Gagnon LP, Thavorn K, Heyland D, D’Egidio G.